Introduction

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In plant training for the professionals is now essential to know in details the
application mode of modern scientific and management issue aiming to familiar
them correctly.

This training is the bridge between the theories and principles with their
practices, in other words between the institution and commercial organization.

SQUARE Pharmaceuticals Limited is committed to ensure between lives through

quality medicine. For this, we selected the SQUARE Pharmaceuticals Limited to
be trained which is already known as one of the tops leading pharmaceutical
company is Bangladesh. I fell proud to take my training in such factory.
All of the employees from top to the bottom of the factory are very much
cooperative and responsive, they help us to understand every operation, simplify
various critical points and make me understand a factory job. we are very much
grateful and our cordial gratitude to them.

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 Company

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Company over view

SQUARE Pharmaceuticals Limited is the largest pharmaceutical company in

Bangladesh and it has been continuously in the 1st position among all national
and multinational companies since 1985. It was established in 1958 and
converted into a public limited company in 1991. The sales turnover of SPL was
more than Taka 5 Billion (US$ 90 million) with about 15% market share (April
2003 – March 2004) having a growth rate of about 16%.

SQUARE today symbolizes a name - a state of mind. But its journey to the growth
and prosperity has been no bed of roses. From the inception in 1958, it has today
burgeoned into one of the top line conglomerates in Bangladesh.

SQUARE Pharmaceuticals Limited, the flagship company, is holding the strong

leadership position in the pharmaceutical industry of Bangladesh since 1985 and
is now on its way to becoming a high performance global player.

Milestones :

1958 : Debut of Square Pharma as a Partnership Firm

1964: Converted into a Private Limited Company

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1974: Technical Collaboration with Janssen Pharmaceutical, Belgium, a
subsidiary of Johnson and Johnson International, USA.

1982: Licensing Agreement signed with F. Hoffmann-La Roche Ltd., Switzerland.

1985: Achieved first position in the Pharmaceutical Market of Bangladesh among

all national and multinational companies.

1987: Pioneer in pharmaceutical export from Bangladesh

1991: Converted in to a Public Limited Company

1994: Initial Public Offering of Square Pharmaceutical Shares

1995: Chemical Division of Square Pharmaceuticals Ltd. starts production of

pharmaceutical bulk products (API).
1997: Won the National Export trophy for exporting pharmaceuticals.

1998: Agro-chemicals & Veterinary Products Division of Square Pharma starts

its operation.

2001: US FDA/UK MCA standard new Pharmaceutical factory goes into

operation built under the supervision of Bovis Lend Lease, UK.

2004: Signing of agreement with ROVIPHARM, Vietnam to manufacture and

market SQUARE products under license in Vietnam.

Secured the top position for the best published accounts and report for 2003 in
the manufacturing category for transparency and excellence in corporate
reporting.

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2005: New State-of- the-Art SQUARE Cephalosporin Ltd. goes into operation;
built under the supervision of TELSTAR S.A. of Spain as per US FDA/ UK MHRA
requirements.

Their Mission

Their mission is to provide quality & innovative healthcare relief for people,
maintain stringently ethical standard in business operation also ensuring benefit
to the shareholders and other stakeholders.

Their Vision

They see business as a means to the wellbeing of the investors, employees and
the society at large, leading to accretion of wealth through financial and moral
gains as a part of the process of the human civilization.

Their Objective

Their objectives are to conduct transparent business operations within the legal &
social frame work with aims to attain the mission reflected by our vision.

Strengths of SQUARE Pharmaceuticals Ltd

- Strong leadership
- House keeping
- Traditional safety culture
- Good discipline
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 - Occupational health

Export

Present Markets

Asia: Bhutan, Cambodia, Macau, Malaysia, Myanmar, Nepal, Iraq, Papua New
Guinea, Sri Lanka, Tajikistan, Uzbekistan, Vietnam, Yemen

Africa: Botswana, Benin, Comoros Islands, Gambia, Ghana, Kenya, Libya,

Mauritius, Mozambique, Malawi, Niger, Rwanda, Sierra Leone, Somalia,
Tanzania

Europe: Kosovo, Ukraine

Markets under Exploration

Asia: Hong Kong, Iran, Laos, Maldives, Philippines, Qatar, Saudi Arabia,
Thailand, UAE

Africa: Algeria, Chad, Nigeria, South Africa, Sudan, Ethiopia

Europe: England, Russia

America: Costa Rica

Major Therapeutic Areas

Their marketed product portfolio covers seven core therapeutic areas

 Alimentary Preparations
 Antiallergy Preparations
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  Antidiabetic Preparations
 Antiparasite Preparations
 Bone Calcium Regulator
 Cardiovascular Preparations
 CNS Preparations
 Drugs for Urinary Incontinence
 Eye and Ear Preparations
 Haematinics
 Lipid Modifying Preparations
 Local Anesthetics
 Mineral Supplements
 NSAIDs and Antigout Preparations
 Penicillins and Cephalosporins
 Quinolone Antibiotics
 Respiratory Tract Preparations
 Systemic Antifungal, Antiviral and Antiprotozoal Agents
 Thyroid Therapy
 Topical Preparations
 Vitamins and Minerals

Dhaka Unit

The Dhaka Unit is about 50 km away in the north of the capital city. Bovis Lend
Lease, UK designed this plant. This is a state of the art manufacturing facility for
oral solid dosage forms and all facilities have been developed meeting the

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requirements of cGMP CFR 21. Dhaka Unit started its operation at the end of
2002.
In the year 2002, the representative of UNICEF, Copenhagen, audited Dhaka
Unit facility and enlisted this plant for their global supply. Besides UNICEF audit,
in 2003, David Begg Associates, an UK based consulting company also audited
this facility and recognized that this plant fulfills the requirement of MHRA (United
Kingdom Medicines and Healthcare Products Regulatory Agency).

Objectives of Dhaka Unit

 Meet challenges of globalization

 Expand export horizon
 Attract contract/ license manufacturing
 Benchmark for pharmaceutical industry in Bangladesh

Dhaka Unit is endowed with the following unique features

1. General Production building

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 • Raw material receiving bay with electrocutors to prevent entering insects

• Two air conditioned warehouses one is for raw materials and another is
for finished goods and packaging components

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 • Electronic controlled (Interlocked) double-door air locks for material entry

• Complete dress change through double change rooms have been

implemented for the personnel with mandatory shower at the first time
entry in a day

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 • All production equipments are modern state of the art from European and
American sources and are cGMP compliance

• Down flow sampling and dispensing booths

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 • Granulation suites are completely closed with vacuum loading and transfer
facilities

• Material handling is performed by Intermediate Bulk Container (IBC)

system-a closed system for efficient and safe handling of bulk materials
(powder/granules).

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 •

IBC cage for powder/granules blending with safety interlock barrier.

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 • IBCs are cleaned through PLC control cleaning cycles with hot, cold and
purified water for effective cleaning

• Materials (powder/granules) are discharged by gravity fed discharge

station which is a closed system

2. Secured reject store independent from production building

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3. QC laboratory
• Independent from production building

• All equipments (HPLC, GLC, FTIR, FTNIR, Infrared spectrophotometer,

Atomic absorption etc) are state of the art and from Japanese, European
and American sources.

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 • All stability studies are performed as per ICH storage guidelines

4. Dedicated Air Handling Units and other building service systems

installed in the mezzanine floor with a focus to prevent cross
contamination.

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5. Building Energy Management Systems (BEMS) to control and monitor
temperature, relative humidity and air pressure differential at the
processing area.

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6. Central Dust Collector to achieve dust free operation at the point of dust
generation in the processing area

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7. Own generation of electricity to ensure uninterrupted power supply
round the clock

8. Purified water meets USP 27 specification. After a series of pretreatment

and softening, softened water is passed through de-ionizer and reverse
osmosis for final purification. Auto sanitization system also exist in the
purified water distribution system.

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9. Central and in-house laundry for factory garment cleaning

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 Orientation
And
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Department of
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Square
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