A Proposal for the Ph.D.

Project

Tittle of thesis

By
Candidate Name

Guide

Co-guide

INTRODUCTION

Importance of proposed research investigation

Rational behind the proposed study

Objectives of the study

 Development of dosage forms like
 Physicochemical characterization and in vitro evaluation of prepared formulations
 In-vivo evaluation in animal model etc…………………………..

Methodology
1. Preformulation studies : You can give brief description for each
 Identification tests
 Micromeritic properties: Bulk Density (Db), tapped density (Dt), angle of
Repose (è), Carr’s compressibility Index (I) and Hausner’s Ratio
 Analytical method for estimation of the drug:
 Drug-exicipient compatibility studies

1
2. Preparation of formulations Give in general

3. Physicochemical characterization and in vitro evaluation of prepared

formulations
Particle size and shape:
Infrared spectroscopy:
Differential scanning calorimetry:
Micromeritic properties:
Yield and drug content:
In Vitro evaluation
hardness, friability, weight variation and drug content.
Dissolution studies:
4. Stability study of optimized formulations
accelerated stability studies in accordance with the ICH guidelines.

5. Pharmacokinetic evaluation in animals

Pharmacokinetic studies will be carried out in suitable animal model.

Statistical Methodology
The data will be analyzed by Student’s t-test or One-way ANOVA and a suitable
post hoc test.

REFERENCES