Name: Stephen Mitchell

Date: 4/11/16

Genomes, Chromosomes, and DNA Web Quest

Topic: Genomes and Chromosomes
Go to: http://ghr.nlm.nih.gov/handbook/hgp/genome
1. What is a genome?
An organisms complete set of DNA, including all of its genes

2. On the left hand side, click on cells and DNA. Explore this site to answer the
following questions:
a. What is a chromosome?
In the nucleus, the DNA molecule is packaged into thread-like structures
and coiled around proteins
b. When are chromosomes visible?
Under a microscope during cell division
c. What is a centromere?
Divides the chromosome into two sections/arms
d. How many chromosomes do people have?
46

Go to: http://learn.genetics.utah.edu/content/begin/traits/karyotype/
3. What is a karyotype?
Organized profile of a person's chromosomes
4. Match the chromosomes to complete the karyotype (turn on hints for help). Is the
karyotype from a male or female? How do you know?
Male, there is a presence of the x and a chromosome
Modeling Instruction AMTA 2012

Unit 6 Growth and Reproduction

Name: Stephen Mitchell

Date: 4/11/16

5. Predict what would happen if a person has the incorrect number of

chromosomes. Write your prediction here.
Make them much different from everyone else
6. Do a quick google search to find the answer to question 5.
Traits would not be inherited by parents
As a class you determined that chromosomes must be duplicated before the cell can
divide. This process is called DNA Replication.
Topic: DNA Replication
Go to: http://www.pbs.org/wgbh/aso/tryit/dna/shockwave.html
Click: DNA replication (upper left) and then click unzip Read the script, answer the
questions below, and then, click OK.
1.

In a real cell, what does the DNA molecule do before it unzips?

DNA Replication

2.

What molecules break the rungs (bases) apart?

Enzymes

Drag the correct bases over to synthesize the new DNA halves.
Read script, answer questions, and then click OK.
3.

How many base pairs are in the real human genome?

3 billion

Modeling Instruction AMTA 2012

Unit 6 Growth and Reproduction

Name: Stephen Mitchell

Date: 4/11/16

Go to: http://nobelprize.org/educational_games/medicine/dna_double_helix/
Click on Play DNA Game; Click next and reading each page, continue to click next
until you come to the game.; Click on organism #1 and match the base pairs as fast as
you can! It is hard.
Click Next and then click on each organism until you identify the one that belongs to
chromosome #1; continue playing the game with the other two chromosomes, filling in
the chart below.
Be careful, other teams may get different results.
Chromosome #
1

How many
chromosomes?
5

How many
base pairs?
125

How many
genes?
25,000

What is the
organism?
Hale Cress

4.4

3,900

Tuberculosis

278

13,700

Malaria
Mosquito

Topic: Mutations
Go to: http://evolution.berkeley.edu/evolibrary/article/mutations_03
Read the information and fill out the table below:
Type of mutation
Substitution

Description
A mutation that exchanges one base
for another

Insertion

Mutations where extra base pairs are

inserted into a new place in the DNA

Deletion
Frameshift

Effect on resulting protein

Changed or switched

New protein formed because what is

added

Mutations where a section of DNA is

lost

Take away something from the protein

Alter a gene so that its message is no

longer correctly parsed

Changed so it is not the same at all

Modeling Instruction AMTA 2012

Unit 6 Growth and Reproduction