Efficacy of Neonatal HBV Vaccination on Liver Caner and Other

Liver Diseases over 30-year Follow-up of the Qidong Hepatitis

B Intervention Study: A Cluster Randomized Controlled Trial
Introduction
Hepatitis B virus (HBV) is a virus that affects the kidney causing
both long-term and short-term illnesses. Hepatitis B virus can be
transmitted through sexual intercourse, blood and birth. Although,
short-term illnesses are usually faint, long-term illnesses usually result
in cancer. Researchers chose to study this subject because they
wanted to investigate whether receiving the Hepatitis B virus
vaccination as a neonatal actually protects against liver cancer later on
in life.
Researchers gathered information on children who had deceased
and lab results, indicating whether HBV was present. Researchers
stress the importance of childhood vaccinations. In addition, to
childhood vaccinations they suggest that vaccinations during young
adulthood may reduce the risk of later cancerous development. The
researchers hypothesis concluded that vaccination during adolescence
may help those that were effected by birth are less likely to contract
cancerous diseases.
Materials and Methods
Researchers did a cluster experiment on newborns. One group of
newborns received the vaccination (vaccination group) and the other

group of newborns did not receive the vaccination (control group). The
information that researchers during early childhood reduces the risk
for liver disease. Researchers examined both groups by testing
whether vaccinations during childhood years prevents liver diseases.
They separated the cluster experiment into two groups, one being
newborns who are receiving the vaccination (vaccination group) and
the other group of newborns who did not receive vaccination (control
group). The vaccination group had received two doses of shots within
the first six months. Both groups were eligible for different catch up
shots when reaching adolescent years (10-14). After receiving a
catch-up shot researchers were then able to determine liver disease
by blood samples.
Results
Out of all the children that were examined during this study
receiving a booster between the ages of 10-14 decreases the severity
of Hepatitis B. Comparing both the vaccination and the control group
receiving the vaccination at an earlier age decreased HBV virus by
84%. There was nothing surprising to the scientists in this study. The
scientists came to the conclusion that after the last follow up, many
were either diagnosed with liver cancer or deceased.
Discussion
Researchers hypothesis concluded that vaccination during
adolescence may help those that were affected by birth less likely to

contract cancerous diseases. The information gathered supported their

hypothesis by concluding at the end of the research that, neonatal
HBV vaccination has significantly protective effect against Primary
Liver Cancer development in young adults. (Chunfeng). Researchers
were able to gather enough data to conclude that HBV vaccinations,
significantly protect against PLC development in young adults. There
were two limitations to the study. The first limitation to the study was
that the study confirmed that PLC was present in two patients. The
second limitation to the study was that they had the patients agree to
participate in the study.
Learning Outcomes
The Science of Biology unifies much of natural science. Life
defies simple definition that all living systems are the most complex
chemical systems on Earth. Life is constrained by the properties of
chemistry and physics. There are seven characteristics of all living
organisms: cellular organization, ordered complexity, sensitivity,
growth, development and reproduction, energy utilization,
homeostasis, and evolutionary adaptation. Evolution is how an entity
changes through time and how the development of modern concept
traced to Darwin, Descent with modification.

Bibliography
Chunfeng Qu, Taoyang Chen, Chunsun Fan, Qimin Zhan, Yuting Wang,
Jianhua Lu,
Ling-ling Lu, Zhengping Ni, Fei Huang, Hongyu Yao, Jian
Zhu, Jian Fan, Yuanrong Zhu, Zhiyuan Wu, Guoting Liu, Wenhong Gao,
Mengya Zang, Dongmei Wang, Min Dai, Chu Chieh Hsia, Yawei Zhang,
Zongtang Sun. Efficacy of Neonatal HBV Vaccination on Liver Cancer
and Other Liver Diseases over 30-year Follow-up of the Qidong
Hepatitis B Intervention Study: A Cluster Randomized Controlled Trial
San Francisco, USA, 2014. POLS Medicine(2014)Print.