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    The aim of this research was to assess in obese patients, the possibility to detect the loss of b cell function using a new approach via nitric oxide assessment. 115 obese patients (93 women and 22 men) mean age 39 (range 1762) were included in the study. 20 patients are undergoing metformin treatment and 63 patients were undergoing antihypertensive agents, patients undergoing insulin or secretagogues treatment were excluded.

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    The aim of this research was to assess in obese patients, the possibility to detect the loss of b cell function using a new approach via nitric oxide assessment. 115 obese patients (93 women and 22 men) mean age 39 (range 1762) were included in the study. 20 patients are undergoing metformin treatment and 63 patients were undergoing antihypertensive agents, patients undergoing insulin or secretagogues treatment were excluded.

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    76 views2 pages

    Fda Clinical Studies Obesity

    Uploaded by

    api-283778857
    The aim of this research was to assess in obese patients, the possibility to detect the loss of b cell function using a new approach via nitric oxide assessment. 115 obese patients (93 women and 22 men) mean age 39 (range 1762) were included in the study. 20 patients are undergoing metformin treatment and 63 patients were undergoing antihypertensive agents, patients undergoing insulin or secretagogues treatment were excluded.

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    of 2

    Beta Cell Function

    NewApproachtoscreenbetacellfunctionfromnitricoxideassessmentinobesepopulationforlarge
    scale.
    http://www.ncbi.nlm.nih.gov/pubmed/22675263
    Abstract
    Background:Today,approximately27%ofAmericansareobese(BMI>30kg/m2)andthiscondition
    increasestheprevalenceofmetabolicsyndromeanddiabetes.TheUKPDSstudysuggeststhatlossofcell
    functioncanbeginatleast10yearsbeforediagnosisandmeancellfunctionwasalreadylessthan50%at
    diagnosis.
    Theaimofthisresearchwastoassessinobesepatients,thepossibilitytodetectthelossofcellfunction
    usinganewapproachvianitricoxide(NO)assessmentfromtheacombinationoftechnologies.
    Method:115obesepatients(93womenand22men)meanage39(range1762),candidatestobariatric
    surgerywereincludedinthestudyandwereundergoingforlaboratorytestsincludingfastingbloodglucose,
    fastinginsulinplasma,andforanexaminationwiththeE.SComplex(LDTechnology,Miami,Florida,USA).
    20patientsareundergoingmetformintreatmentand63patientswereundergoingantihypertensiveagents,
    patientsundergoinginsulinorsecretagoguestreatmentwereexcludedfromthestudy.
    TheElectrosensorcomplex(ESComplex)providesanewwaytoassessNOproductionusing5
    technologiesmanagedbysoftware:1)Galvanicskinresponse2)photoelectricalplethysmography3)heart
    ratevariabilityanalysis,4)bioimpedanceanalysisand5)bloodpressureoscillometricmeasurements.
    TheHomeostasismodelassessment2,percentcellfunction(HOMA2%)algorithmhadbeencalculated
    fromthefastingbloodglucoseandthefastinginsulinplasmausingfreesoftwareprovidedbyTheUniversity
    ofOxfordDiabetesTrialUnit.
    TheElectrosensorcomplex,percent(ESC%)algorithmhadbeencalculatedfromtheE.SComplexdata
    andstatisticalneuralnetwork.
    StatisticalanalysiswasperformedtocorrelateofESC%andHOMA2%usingthecoefficientof
    correlationandtheSpearman'scoefficientofrankcorrelation.
    Also,Receiveroperatingcharacteristic(ROC)curveswasperformedtodeterminethespecificityand
    sensitivityofESC%todetectHOMA2%value<100.
    Results:

    ThecoefficientofcorrelationESC%andHOMA2%isr=0.72(usingLogvalues)andtheSpearman's
    coefficientofrankcorrelation(rho)was0.799andsignificancelevelfor(P<0.0001).
    ESC%hadasensitivityof77.14%andspecificityof78.21%(cutoff<=157correspondingat40%after
    conversioninscale0100%)todetectHOMA2%value<100(P<0.0001).
    Conclusion:TheESC%algorithmhasahighpredictivecorrelationwiththeHOMA2%,andgood
    specificityandsensitivitytodetectHOMA2%value<100,therefore,theESComplexprovidingnitricoxide
    assessmentwillbeanewwaytoscreenthecellfunctioninobesepopulationforlargescale.Henceatool
    whichiseasytoadminister,noninvasive,andcosteffectivewouldbeofadvantageandofgreatbenefitfor
    betacellfunctionscreeninginobesepatients.
    Keywords:cellfunction,electrosensorComplex,nitricoxideassessment,ESC%algorithm,HOMA2%
    algorithm,obesepopulation,largescalescreening.

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