6/5/2014 Oxygen allows less ventilation

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Supplemental oxygenation and minute ventilation
Calculated alveolar PO2 (PAO2, blue and green solid lines) and arterial
PCO2 (PaCO2, red dashed line) as a function of alveolar ventilation in
patients undergoing mechanical ventilation. Calculated PAO2 is shown
for two levels of inspired oxygen concentration. For an FiO2 of 0.21
(blue) and alveolar ventilation of 3.6 L/min, the predicted PAO2 is 100
mmHg (point A) and the PaCO2 is 40 mmHg (point A'). When FiO2 is
0.30, alveolar ventilation can be reduced to 1.6 L/min, while
maintaining the PAO2 at 100 mmHg (point B). The corresponding
PaCO2 at this level is 192 mmHg (point B'). The rate of carbon dioxide
excretion (VCO2) is set at 200 mL/min for all calculations. The vertical
line through A and A' indicates normal values.
Redrawn from Bidani, A, Tzouanakis, AE, Cardenas, VJ, et al, JAMA 1994;
272:957.
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