CHRI STI NA VALERO UVA DI ETETI C I NTERNSHI P Presentation Overview I. Overview of HIV I. Definition and Virology II. Incidence III. Transmission IV. Disease Stages V. Important Labs of the Disease VI. Opportunistic Infections VII. Antiretroviral Therapy (ART) VIII. Life Expectancy IX. Pregnancy and Breastfeeding II. HIV/AIDS and Malnutrition I. Malnutrition Incidence II. Nutrition Implications of the Disease III. Medical Nutrition Therapy I. Goals of Therapy II. Nutrition Interventions IV. Role of the RD V. Case Study VI. Summary
Learning Objectives 1. Be able to define HIV and AIDS and distinguish between the two. 2. Have a basic understanding of HIV virology. 3. Learn how HIV is transmitted, including the fluids that transmit the disease. 4. Be able to interpret CD4 count and Viral Load. 5. Be able to define opportunistic infection. 6. Have an understanding of the goals of Antiretroviral Therapy and the side effects of ART drug use.
Learning Objectives, Continued 7. Become familiar with the nutrition implications associated with the disease and its treatment. 8. Have an understanding of the connection between HIV/AIDS and malnutrition. 9. Learn the importance of MNT and the goals of MNT in this patient population. 10. Become familiar with the common nutrition diagnoses in these patients and identify appropriate nutrition interventions 11. Be able to define neutropenic diet and identify what this diet entails. 12. Understand the role of the Registered Dietitian in the care of this patient population.
What is HIV? Human Immunodeficiency Virus- retrovirus that causes progressive failure of the immune system, allowing life-threatening opportunistic infections and cancers to thrive. Eventually causes Acquired Immunodeficiency Syndrome 1 HIV infects helper T cells (CD4+ cells), macrophages, and dendritic cells 2
These cells activate the immune response when they detect intruders
What is HIV? HIV leads to low level of CD4 cells by binding to the surface and becoming a part of the cells 3 As CD4 cells multiply to fight infection, they make more copies of HIV 3 Leads to gradual decline of CD4 cell count; HIV takes over. When CD4 cell count declines below a critical level, cell-mediated immunity is lost and the body becomes progressively more susceptible to opportunistic infections 3 HIV Virology: Retrovirus: carries its genetic material in the form of mRNA 4 Targets a host cell Once inside the cell, the virus uses its own reverse transcriptase enzyme to produce DNA from its RNA genome 4 Reverse of normal virus: DNA RNA proteins 4 The new DNA is then incorporated into the host cells genome by the integrase enzyme 4 Now, the host cell treats the viral DNA as part of its own genome 4 Translates and transcribes the viral genes as the cells own genome continues, and new copies of the virus are made 4
http://www.tbiomed.com/ content/7/1/5/figure/F1?h ighres=y HIV Incidence CDC estimates that >1.1 million people are living with HIV in the US 5 ~1 in 6 people (15.8%) are unaware of their infection 5 Over the past decade, the number of people living with HIV has increased 5 HIV Demographics Gay, bisexual, and other men who have sex with men are most seriously affected by HIV 5
AIDS affects nearly 7 times more African Americans and 3 times more Hispanics than whites 5
Estimated new # of HIV infections was highest among individuals aged 25-34 in 2010, followed by age group of 13-24 5
Transmission Fluids of transmission include: Blood Semen/pre-seminal fluid Vaginal fluid Breast milk Sweat, saliva, tears, and urine have not been shown to transmit HIV 5
Transmission Fluids must come in contact with a mucous membrane, damaged tissue, or be directly injected into the bloodstream. HIV can enter the body through: Lining of the anus, rectum, vagina and/or cervix Opening to the penis Mouth that has sores or bleeding gums Cuts or sores Unbroken skin 5
Transmission Common ways HIV is transmitted: Anal, vaginal, or oral sex (most common) Sharing needles with someone who is HIV+ (2 nd most common) Before or during birth Through breastfeeding Through transfusion of infected blood or blood clotting factors oHave no fear, all donated blood in the US is tested for HIV! 5
Progression of HIV Four Stages of HIV Acute Infection Clinical Latency Symptomatic HIV Infection AIDS Two main biomarkers to assess disease progression are CD4+ T-cell Count (CD4 Count) and Viral Load 1
CD4 Count Used as major indicator of immune function; strongest predictor of disease progression 1
Used to determine when to initiate ART 1
CD4 Count (cells/mm 3 ) Classification 500-1,000 Normal <500 Symptomatic HIV (Stage III) <350 Start ART treatment <200 Qualification for AIDS 1
Viral Load (HIV RNA) Level of HIV in the blood Helps monitor disease progression, decide whether to start treatment If viral load is high, CD4 count is low No normal viral load Antiretroviral medications work by keeping HIV from reproducing in the body, lowering viral load Strongest indicator of the efficacy of ART 5
Stage 1: Acute Infection 2-4 weeks after infection 50% of people experience symptoms such as fever, malaise, myalgia, swollen lymph nodes for 2-4 weeks, but they subside after 1-2 weeks Rarely diagnosed at this stage (symptoms too non-specific) Large amounts of virus are being produced in the body oUses CD4 cells to replicate and destroys them in the process oEventually, viral set point: relatively stable level of virus in the body High risk of spreading d/t high HIV levels in blood 1
Stage 2: Clinical Latency (Asymptomatic HIV) Virus is living and replicating in the body but symptoms are absent Typically lasts ~10 years for those not on Antiretroviral Therapy (ART) May live with clinical latency for decades if on ART Can still transmit disease 5
Stage 3: Symptomatic HIV When CD4 count reaches <500 More susceptible to developing signs and symptoms Persistent fevers, chronic diarrhea, unexplained weight loss, loss of LBM with/without weight loss, thrush, herpes zoster, peripheral neuropathy HIV has slowly broken down the immune system and it can no longer fight the virus 5
Characterized by increased risk for opportunistic infections (OIs) Can also be diagnosed with AIDS if one or more OIs develop without a low CD4 count CDC has named >20 OIs as diagnostic for AIDS Bacterial infections, viral infections, fungi, parasites 5
Shows CD4 levels and Viral Load over the course of an untreated infection http://www.newworldencyclopedia.org/entry/AIDS
Life Expectancy with AIDS Without treatment: 3 years Without treatment but WITH an opportunistic infection: 1 year With ART: near normal lifespan! HIV most likely wont progress to AIDS 5
Factors the Shorten Disease Progression Older Age Co-infection with other viruses Poor nutrition Severe Stress Genetic Background 5
Factors that Delay Disease Progression Taking ART Staying in HIV care and listening to doctors Good nutrition status and LBM before becoming infected with HIV Genetic background 5
Antiretroviral Therapy (ART) Sometimes called HAART- Highly Active Antiretroviral Therapy Introduced in 1996- changed HIV/AIDS outcomes dramatically Overall AIDS-related deaths, incidence of AIDS, and incidence of opportunistic infections substantially declined 6 Goal is to achieve and maintain viral suppression, reduce HIV-related morbidity and mortality, improve quality of life, and restore/preserve immune function 1
>20 antiretroviral agents from 6 mechanistic classes of drugs 1 Antiretroviral Therapy Pts usually take 3+ ART medications Treatment is lifelong Increases risks of side effects, toxicity, metabolic complications Multiple side effects Potential Drug-Nutrient Interactions Non-adherence can lead to drug resistance 1
Drug Classes Nucleoside and nucleotide reverse transcriptase inhibitors (NRTIs) Nonnucleoside reverse transcriptase inhibitors (NNRTIs) Protease Inhibitors (PIs) Fusion Inhibitors Chemokine receptor 5 (CCR5) antagonists Integrase strand transfer inhibitors (INSTIs) A regimen that includes a combination of drug classes used most often to combat the disease in multiple ways and to prevent drug resistance 1
Drug-Nutrient Interactions Grapefruit juice and PIs 1
Compete with cytochrome P450 enzyme: major enzymes involved in drug metabolism and bioactivation 1
May cause increase or decrease in blood levels of the drug 1
Timing of food with some medications can effect efficacy and/or cause side effects 1 Some meds should be taken with a meal while others on an empty stomach Takes high health literacy and great responsibility for self-care Costs of ART As of 2006, ART averaged $10,000 - $15,000/year per patient 7
But, studies show that ART is highly cost-effective 7
Sicker HIV-infected patients have a total annual health care expenditure 2.5 times higher than healthier ones 7
Opportunistic Infections Infections that do not generally occur in healthy individuals with strong immune systems
Called opportunistic because they take advantage of the opportunity to infect a weakened immune system Can be fatal in people living with HIV/AIDS ART can help prevent OIs by increasing the number of CD4 cells 1
Opportunistic Infections Most common OIs include: Tuberculosis- bacterial infection that affects the lungs but can spread to other organs Kaposis sarcoma- can cause lesions on the body and in the mouth, or even affect internal organs and spread to rest of body without external signs Thrush (candidiasis)- fungal infection of the mucus membrane lining the mouth and tongue Cryptosporidiosis- parasitic infection of the small intestine that causes severe chronic diarrhea. Can lead to severe loss of muscle mass and malnutrition 1
https://www.womenshealth.gov/hiv-aids/opportunistic- infections-and-other-conditions/ Pregnancy, Breastfeeding, and Transmission Mother-to-child transmission can occur during pregnancy, labor or delivery, or through breastfeeding 1
Without ART, there is a 25% chance of mom passing the virus on to baby during pregnancy or delivery 9
30-45% chance of passing virus to baby through breastfeeding 9 Some ART medications do cross the placenta 11 Baby often receives ART treatment (syrup form) for four weeks after birth 11 Pregnancy Recommendations CDC recommends: Starting ART before trying to get pregnant Taking ART throughout pregnancy and delivery Delivering baby via C-section Avoiding breastfeeding if there is a safe alternative 5
Complying with all above recommendations: <2% chance of passing the infection to baby 5
HIV/AIDS and Malnutrition HIV/AIDS and Malnutrition HIV/AIDS Decreased Immunity Increased Nutrient Requirements Malnutrition Increased Susceptibility to Infections HIV-Related Malnutrition Suspected mechanisms of weight loss and malnutrition include: Inadequate dietary intakes Nutrient losses Metabolic changes 1
Immune system working harder increased requirements Insulin resistance Lipodystrophy Reduced intestinal absorption d/t damage in villi, inflammation 12
Malnutrition, specifically wasting, is an important predictor of HIV progression 1
Nutrition Implications Decrease in LBM Persistent N/V/D Anorexia Weight Loss Malabsorption
Nutrition Implications HIV-Induced Encephalopathy (AIDS Dementia)- degenerative disease of the brain caused by HIV infection Inability to prepare food and feed self HIV-Induced Enteropathy- effect of HIV on enteric mucosa Chronic diarrhea, decreased appetite, weight loss, malabsorption, changes in cognition Kaposis Sarcoma Lesions in mouth or esophagus: difficulty chewing and swallowing Lesions in intestine: obstruction and diarrhea 1
Nutrition Implications Cytomegalovirus Enteritis, colitis, weight loss, decreased appetite Tuberculosis Malabsorption, weight loss, altered metabolism, fatigue, anorexia Pneumocystis pneumonia (PCP) Difficulty chewing and swallowing caused by SOB Cryptosporidiosis Cramping, electrolyte imbalances, diarrhea, weight loss 1
http://www.life-worldwide.org/fungal- diseases/oral-candidiasis/ Nutrition Implications HIV-associated lipodystrophy syndrome (HALS)- abnormal distribution and metabolism of fat Fat redistribution, insulin resistance, hypertriglyceridemia Excess fat accumulation or loss in various parts of the body- increased fat in trunk, loss of fat in face and extremities common With access to ART, new nutrition issues have arisen due to HALS HIV-related death has shifted from OIs to chronic diseases: heart disease and diabetes 1
AIDS-Related Wasting Syndrome 10% weight loss in 6 months with Diarrhea >30 days without known cause OR Fever and chronic weakness >30 days in the absence of a concurrent illness other than HIV that would explain the findings 1
Medical Nutrition Therapy Importance of MNT Malnutrition with HIV infection has been associated with: Increased mortality Accelerated disease progression Loss of muscle protein mass Impairment of strength and functional status An unintentional weight loss as little as 5% has been associated with increased morbidity and mortality 13
Goals of MNT Optimize nutrition status, immunity, and well-being Maintain a healthy weight and lean body mass Prevent nutrient deficiencies Reduce the risk of co-morbidities Maximize the effectiveness of medical and ART treatments 1
Nutrition Assessment: Factors to Consider Type Factor Medical Stage of HIV disease Comorbidities Presence of Opportunistic Infection Metabolic Complications Biochemical measurements Physical Changes in body shape Weight or growth concerns Oral or GI symptoms Functional Status Anthropometrics 1
Type Factor Social Living environment (support from family/friends) Behavioral concerns or unusual eating habits Mental health (depression?) Economical Barriers to nutrition (access to food, financial resources) Nutritional Typical intake Food shopping and preparation Food allergies and intolerances Vitamin, mineral, and use of other supplements Alcohol and drug use 1
Nutrition Assessment Energy Recommendations Individuals with well-controlled HIV: mirror same recommendations as healthy individuals 1
Establish the individuals need to gain, lose, or maintain weight Vary considerably on case to case basis Could use 25-45 kcal/kg UBW OR Harris Benedict with stress factor of 1.2-1.8 1
After an OI, nutritional requirements increase by 20%-50% 1
Increased REE common in pts with HIV, especially those with OIs, but TEE actually decreases 13
Decrease in TEE illustrates that HIV more significantly decreases the infected persons activity level 13
Thus, decreased energy intake = primary contributor to wasting 13
Protein Recommendations Much like energy recommendations, vary from case to case basis Must consider comorbidities, presence of OI 14
Current DRI of 0.8 g/kg BW recommended 14
Deficiency of protein stores and altered protein metabolism occur in HIV/AIDS patients, but no clinical evidence exists support increasing the proportion of protein above normal levels 14
With presence of OI, additional 10% is recommended d/t increased protein turnover 14
Fluid Recommendations Standard requirements to meet needs: 30-35 ml/kg body weight 14
Consider increasing fluid requirements with fever, N/V/D, exercise 14
Caffeinated beverages do not count 14
Exercise Recommendations LBM is very important in helping the body resist OIs and to recover after infection HIV wasting depletes LBM 1
Resistance exercise important!
Common Nutrition Diagnoses Inadequate oral food and beverage intake Increased nutrient needs Swallowing difficulty Altered GI function Food-medication interaction Involuntary weight loss
Overweight and obesity Food and nutrition-related knowledge deficit Over-supplementation Impaired ability to prepare foods or meals Inadequate access to food Intake of unsafe foods 1
Nutrition Interventions: Diarrhea Bland foods Avoid fatty, greasy, or spicy foods Limit caffeine Low-fiber fruits (like applesauce and bananas) Avoid dairy products Replace electrolytes with oral hydration drinks and broths 1
Nutrition Interventions: N/V Keep log of the causes Small, frequent meals Bland foods (rice, potatoes) Limit high-fat, greasy foods Avoid foods with strong odors Cool and clear liquids Scheduling anti-emetics 1
Nutrition Interventions: Taste Changes Use spices and herbs Avoid canned foods and canned oral supplements Use plastic utensils 1
Nutrition Interventions: Weight Loss Nutrient-dense foods Milkshakes, lean protein, vegetables, fruits, whole grains, trail mixes Add dry milk or protein powder to oatmeal, casseroles, milkshakes Add rice, barely, and legumes to soups Oral supplements Small frequent meals 1
Nutrition Interventions: Thrush Soft foods Oatmeal, scrambled eggs, milkshakes, applesauce Avoiding spicy or acidic foods Moisten foods with gravies and sauces Watch temperature of foods- cold and room temperature foods often more accepted Use a straw 1
Nutrition Interventions: Decreased Appetite Mild exercise to stimulate appetite Small, frequent meals Avoid drinking too much right before or during meals Avoid carbonated drinks Eat with company Choose favorite foods Appetite Stimulants? 1
In a 12-week study of 271 male patients with AIDS wasting, those receiving 800 mg of megestrol acetate/day consumed 500 kcal more/day and gained 4 kg compared with placebo-treated patients (who had weight loss of 0.7 kg), in association with an improved quality of life 16
Appetite Stimulants Dronabinol Primary active compound in marijuana- approved by FDA for HIV-associated anorexia 12
In a RDBPC multicenter trial in patients with HIV-associated weight loss treated with dronabinol (2.5 mg BID) produced significant increases in self- reported appetite and decreases in nausea but did not significantly increase weight over a 6-week treatment period 12,17
Food Safety Contaminated food = more serious consequences for persons with HIV/AIDS Avoid raw or undercooked meats, seafood, and eggs Includes egg yolks and sushi Ensure only pasteurized milk and cheese products, juices Prevent cross-contamination: use separate cutting boards for raw meats Wash fruits and vegetables Wash hands 1
Neutropenic Diets Also known as an Immunocompromised Diet Generally recommended for patients with a WBC count <500 cells/mm3 Eliminates raw fruits and vegetables, meat cooked less than well done, cured meats, yogurt, aged cheese and prepared salads 14
Role of the RD RDs Role Assess patients nutrition status by looking at weight history, medications, lab values, presence of OIs, etc. Determine nutrition-related goals for patients, including weight gain/loss/maintenance goals and exercise goals Provide appropriate interventions based on nutrition-related goals Provide recommendations to improve nutritional status, immunity, and quality of life Address DNIs and manage side effects of ART Identify barriers to desirable food intake Encourage adherence to ART Case Study 55 yo male with hx of HIV on ART admitted for constant watery diarrhea x3 weeks w/ decreased appetite and severe weight loss. UBW: 141#; CW: 107# Last CD4: 67; Viral Load: Undetectable AST: 36(H); ALT: 244 (H) Meds: Darunavir, Etravirine, Raltegravir Reports 8 watery stools/day x7 days Eating ~1 meal/day + 2-3 Ensures Tested for 10 different microorganisms Received Acid-Fast Bacillius smear, bacterial, blood, fungal, stool, and urine cultures
Case Study Do you need a detectable Viral Load to have HIV? Based on this patients CD4 count, does he have AIDS? Why might his AST and ALT lab values be high? Are there any DNIs this patient needs to be aware of with his specific ART regimen? What are some of the nutritional interventions you can recommend for this patient? Consider managing diarrhea Consider hydration status
Summary People living with HIV experience high rates of side effects and comorbidities associated with HIV and/or with ART treatments The specific MNT should be individualized for each patient as there are multiple comorbidities, medications, and opportunistic infections that affect nutrition status To prevent loss of weight and LBM, all HIV-infected patients should be encouraged to maintain adequate energy intake and engage in moderate exercise Questions? Scuse me I have a question! References 1. Mahan, L. Kathleen., Escott-Stump, Sylvia., Raymond, Janice L.Krause, Marie V. (Eds.) (2012) Krause's food & the nutrition care process /St. Louis, Mo. : Elsevier/Saunders. 2. Garg H, Mohl J, Joshi A. HIV-1 induced bystander apoptosis. Viruses. 2012;4: 302043. 3. Cunningham A, Donaghy H, Harman A, Kim M, Turville S. Manipulation of dendritic cell function by viruses. Current opinion in microbiology . 2010; 13: 524529. 4. http://en.wikipedia.org/wiki/Retrovirus#cite_ref-KurthBannert_1-0. 5. U.S. Department of Health and Human Services. HIV/AIDS Basics. http://www.aids.gov/. 6. Keithley JK, Swanson B, Murphy M et al. HIV/AIDS and Nutrition Implications for Disease Management. Nursing Case Management. 2000;5:52-62. 7. Center for Disease Control and Prevention. HIV Cost-Effectiveness. 2013. http://www.cdc.gov/hiv/prevention/ongoing/costeffectiveness/.
References 8. Wilson MG, Chambers L, Bacon J et al. Issues of comorbidity in HIV/AIDS: An overview of systematic reviews Roundtable Draft. The Ontario HIV Treatment Network. 2012. Accessed at: http://www.ohtnweb.ca/OHTNWebAP/Publications/PDF/cihr_review_co- morbidities_report_2010-12-07_final.pdf 9. WHO Department of Nutrition for Health and Development. HIV Transmission through breastfeeding: a review of the available evidence. 2005. Accessed at: http://www.who.int/nutrition/topics/Paper_5_Infant_Feeding_bangkok.pdf 10. NAM Aidsmap. Mother-to-baby transmission. 2001. Accessed at: http://www.aidsmap.com/Mother-to-baby-transmission/page/1044918/ 11. NAM. HIV & AIDS Treatment in Practice. NAM. 2005;47. Accessed at http://www.aidsmap.com/HIV-and-malnutrition/page/1445213/#item1037578. 12. Grinspoon S, Mulligan K, and Department of Health and Human Services Working Group on the Prevention and Treatment of Wasting and Weight Loss. Weight Loss and Wasting in Patients Infected with Human Immunodeficiency Virus. Clin Infect Dis. 2003:S69-S78. Accessed at: http://cid.oxfordjournals.org/content/36/Supplement_2/S69.long
References 14. Macallan DC, Noble C, Baldwin C, Jebb SA, Prentice AM. Energy expenditure and wasting in human immunodeficiency virus infection. N Engl J Med. 1995;333:83-88. 15. Morrison Healthcare Food Services. Manual of Clinical Nutrition Management. 2000. Retrieved at: http://library.ncahec.net/reserve/Diet_Manual_10-00.pdf. 16. Wood, AJ, Corcoran C, Grinspoon, S. Treatments for wasting in patients with the acquired immunodeficiency syndrome. N Engl J Med. 1999;340(22): 1740-1750. 17. Schambelan M, Zackin R, Mulligan K, et al. Effect of testosterone (T) on the response to megestrol acetate (MA) in patients with HIV-associated wasting: a randomized, double-blind placebo-controlled trial (ACTG 313) Program and abstracts of the 8th Conference on Retroviruses and Opportunistic Infections. 2001;236. 17. Beal JE, Olson R, Laubenstein L, et al. Dronabinol as a treatment for anorexia associated with weight loss in patients with AIDS. J Pain Symptom Manage. 1995;10:89-97.