Sanam Soomro Dr.

Ziemys and Diffusion of Drugs

PS:0960600

Dr. Ziemyss lecture was mostly about diffusion in the body and how it is relevant to drug delivery. Bulk diffusion is studied through dye in a liquid but in biology endothelial layers, polymers like extracellular matrix, and cancerous environments, hinder drug diffusion. The problem arises when researchers have to figure out how to bypass these hindrances to deliver drugs into deep tissue. These drug carriers can be nanochannels or nanopores. Nanochannels are implants that shape diffusion and have a linear release rather exponential. Nanopores are injectable and can be diagnostic. A polymer matrix can also be used. Molecular dynamics that need to be considered are chemical interactions, particle interactions due to a force field and Newtonian mechanics that deals with motion and time. Partitioning is another important factor in drug delivery because most drugs are hydrophobic and dont readily dissolve in bodily fluids thus have different diffusion patterns. The different phases of drug and fluids cause different transport phenomenon. This also allows certain drugs to stick to different materials causing a different kind of hindrance depending on where the drug is being transported. Layering drugs with different materials that facilitate delivery by the drug layers interacting with different bodily fluids or materials differently can use this property. In conclusion, Dr. Ziemyss lecture was interesting because it showed how diffusion in the body is not easily modeled and so predicting how drugs are transported and how they interact with the body can be an interesting engineering problem to research.