TEST 1 Name:__________________________ Group:__________________________ Date:__________________

1. Liddle syndrome is characterized by each of the following except: A. Chronic hypokalemia B. Hypotension C. Suppressed serum aldosterone D. Suppressed plasma renin activity (PRA) E. Metabolic alkalosis 2. Each of the following is seen as clinical manifestations of hypokalemia except: A. Arrhythmias B. Worsening Hypertension C. Rhabdomyolysis D. Insulin release E. Metabolic alkalosis 3. Hypokalemia can be exacerbated by each of the following except: A. Glucose administration B. Hypermagnesemia C. Digitalis D. Catecholamines E. Aldosterone 4. Which potassium supplement is preferred in the treatment of hypokalemia in patients without EKG changes and a functional GI tract? A. Oral potassium chloride (KCL) B. Oral potassium phosphate (K phos) C. Intravenous potassium supplementation D. Oral Potassium bicarbonate 5. A 20-year-old man is found to be hypertensive and hypokalemic. A resident taking a careful history discovers that the patient is extremely fond of licorice. Question. Which of the following genetic defects produces a similar syndrome? (a) Mutation in the gene for the inwardly rectifying potassium channel (ROMK) (b) Mutation in the gene for the basolateral chloride channel (CLCNKB) (c) Mutation in the gene for the sodium-chloride cotransporter (d) Mutation in the gene for 11--hydroxysteroid dehydrogenase (e) A chimeric gene with portions of the 11--hydroxylase gene and the aldosterone synthesis gene
receptors themselves have similar affinities for cortisol and aldosterone, the deficiency allows these receptors to be occupied by cortisol, which

normally circulates at much higher plasma levels than aldosterone. Licorice contains glycyrrhetinic acid and mimics the hereditary syndrome because it inhibits 11--hydroxysteroid dehydrogenase