* Escherichia Coli

*Enterococuss Faecalis
*Kleibshiella
*Pseudomonas Aeruginosa
PATHOPHYSIOLOGY

(Bacterial infection)

Ascends to the Kidney

Infection at : Renal Pelvis, Tubules and Interstitial Tissues of one or both Kidney

Release of Inflammatory Chemical Mediators

_

Chemotaxis Increased blood flow Increase capillary Release of cytokines

Permeability

Attraction of Increase blood cell Fluid Shift

Leukocytes Delivery
Production of Pain on lumbar Dysuria
Host cell produces
Swelling leukocytes area & abdomen
endogenous pyrogens
Diapedesis

Phagocytosis Pressure on nerves Leukocytosis

Accelerates set point
of
hypothalmic
Pus
thermo regulatory
Abscess
center
Pyuria

Stimulation of visceral afferent pathway

Vasoconstriction
 Stimulation of medullary vomiting center
Fever

Nausea Vasodilation Increased

metabolism

Vomiting Increased
Oxygen demand
Cerebral vasodilation Flushed skin

Poor appetite
Headache Increase RR
Increase HR Malaise

Weight loss Increase vapor loss

Fatigue

Dehydration

Excessive thirst

Polyuria

CHRONIC PYELONEPHRITIS
Persistent recurring infection
Progressive scarring of kidney
Renal failure

Septic shock