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  • PI3 Kinase Akt Signaling: mTORC2

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    alexandru_mg3
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    This document provides an overview of the PI3K/Akt signaling pathway. It shows that mTORC2 activates Akt which then activates or inactivates many downstream targets involved in processes like protein synthesis, glucose metabolism, cell survival, proliferation, and neuroscience. These targets include factors like GSK-3, TSC1/2, FoxO1, and MDM2. The diagram also indicates how various receptors and proteins can activate or inhibit nodes within this complex signaling network.

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    Akt_PKB

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    Akt_PKB

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    This document provides an overview of the PI3K/Akt signaling pathway. It shows that mTORC2 activates Akt which then activates or inactivates many downstream targets involved in processes like protein synthesis, glucose metabolism, cell survival, proliferation, and neuroscience. These targets include factors like GSK-3, TSC1/2, FoxO1, and MDM2. The diagram also indicates how various receptors and proteins can activate or inhibit nodes within this complex signaling network.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    23 views0 pages

    PI3 Kinase Akt Signaling: mTORC2

    Uploaded by

    alexandru_mg3
    This document provides an overview of the PI3K/Akt signaling pathway. It shows that mTORC2 activates Akt which then activates or inactivates many downstream targets involved in processes like protein synthesis, glucose metabolism, cell survival, proliferation, and neuroscience. These targets include factors like GSK-3, TSC1/2, FoxO1, and MDM2. The diagram also indicates how various receptors and proteins can activate or inhibit nodes within this complex signaling network.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PDF, TXT or read online from Scribd
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    mTORC2

    Akt
    Akt
    p70 S6K
    P
    I
    3
    K
    P
    I
    3
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    P
    a
    x
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    n
    GSK-3
    PHLPP CTMP
    Lamin A
    PP2A
    Tpl2
    IKK
    eNOS
    GS
    Bad
    Bcl-2
    FoxO1
    TSC1
    TSC2
    PDCD4
    AS160
    PFKFB2
    PIP5K
    S6
    p53
    MDM2
    Bim
    Bax
    p27 Kip1
    p21
    Waf1/Cip1
    14-3-3
    Cyclin D1
    G
    GTP
    PTEN
    PDK1
    Syk
    Jak1
    FAK
    ILK
    P
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    3
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    P
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    3
    K
    P
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    K
    XIAP
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    Integrin
    Cytokine
    Receptor
    PDK1
    G
    BCAP
    Lyn
    Ag
    Ataxin-1
    Huntingtin
    GABA
    A
    R
    PRAS40
    GPCR
    RTK
    CD19
    BCR
    PIP
    3 PIP
    3
    mTOR
    Rictor
    Sin1 PRR5
    GL
    DEPTOR
    Raptor
    GL
    mTOR
    DEPTOR
    mTORC1
    mTORC1
    mTORC2
    4E-
    BP1
    ATG13
    /
    /
    Blocks
    Aggregation
    Promotes
    Neuroprotection
    Synaptic
    Signaling
    mIg
    mIg
    Cytosolic
    Sequestration
    Cardiovascular
    Homeostasis
    NF-B
    Pathway
    Organization
    of Nuclear
    Proteins
    Cell Cycle
    Apoptosis
    Aggregation
    Neurodegeneration
    Inhibits Apoptosis
    Inhibits
    Autophagy
    Glycogen
    Synthesis
    Glucose
    Transport
    Glycolysis
    Membrane
    Recruitment
    and Activation
    Membrane
    Recruitment
    and Activation
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    PI3 Kinase Akt Signaling
    www.cellsignal.com
    2003 2011 Cell Signaling Technology, Inc. PI3K / Akt Signaling created January 2003 revised October 2011
    Direct Stimulatory Modification
    Kinase
    Phosphatase
    Caspase
    Receptor
    Cyclin, pro-apoptotic
    Enzyme
    pro-survival
    GAP / GEF
    GTPase
    G-protein, ribosomal subunit
    Transcription Factor
    Transcriptional Stimulation
    Transcriptional Inhibition
    Translocation
    Separation of Subunits or Cleavage Products
    Joining of Subunits
    Direct Inhibitory Modification
    Multistep Stimulatory Modification
    Multistep Inhibitory Modification
    Tentative Stimulatory Modification
    Tentative Inhibitory Modification
    Signaling Pathways Key
    www.cellsignal.com
    2003 - 2010 Cell Signaling Technology, Inc.
    Acetylase
    Deacetylase

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