WHO Histological Classification of Gastrointestinal Tumours

Esophageal Tumours
1. Epithelial tumours: a. Squamous cell papilloma b. Intraepithelial neoplasia i. Squamous ii. Glandular (Adenoma) c. Carcinoma: i. Squamous cell carcinoma ii. Verrucous (Squamous) carcinoma iii. Spindle cell (Squamous) carcinoma iv. Adenocarcinoma v. Adenosquamous carcinoma vi. Mucoepidermal carcinoma vii. Adenoid cystic carcinoma viii. Small cell carcinoma ix. Undifferentiated carcinoma x. Other d. Carcinoid tumour 2. Non-Epithelial tumours: a. Leiomyoma b. Lipoma c. Granular cell tumour d. Gastrointestinal stromal tumour

i. Benigh ii. Uncertain malignant potential iii. Malignant e. Leiomyosarcoma f. Rhabdomyosarcoma g. Kaposis sarcoma h. Malignant melanoma i. Other

3. Secondary tumours

Stomach:
1. Epithelial tumours: a. Intraepithelial neoplasia-Adenoma b. Carcinoma: i. Adenocarcinoma: 1. Diffuse type 2. Intestinal type ii. Papillary adenocarcinoma iii. Tubular adenocarcinoma iv. Mucinous adenocarcinoma v. Signet-ring cell carcinoma vi. Adenosquamous carcinoma vii. Squamous cell carcinoma viii. Small cell carcinoma ix. Undifferentiated carcinoma x. Others c. Carcinoid (Well differentiated endocrine neoplasm)

2. Non-epithelial: a. Leiomyoma b. Schwannoma c. Granular cell tumour d. Leiomyosarcoma e. Gastrointestinal Stromal tumour: i. Benigh ii. Uncertain malignant potential iii. Malignant f. Kaposis sarcoma g. Other h. Malignant Lymphomas: i. Marginal zone B-cell lymphoma of MALT( Mucosal Associated Lymphoid Tissues) ii. Mantle cell lymphoma iii. Diffuse large B-cell lymphoma iv. Other i. Secondary tumours

Small Intestine:
1. Epithelial tumours: a. Adenoma i. Tubular ii. Villous iii. Tubulovillous b. Intraepithelial neoplasia (dysplasia) associated with chronic inflammatory diseases i. Low-grade glandular intraepithelial neoplasia

ii. High-grade glandular intraepithelial neoplasia c. Carcinoma: i. Adenocarcinoma ii. Mucinous carcinoma iii. Signet-ring cell carcinoma iv. Small cell carcinoma v. Squamous cell carcinoma vi. Adenonsquamous carcinoma vii. Medullary carcinoma viii. Undifferentiated carcinoma d. Carcinoid (Well differentiated endocrine neoplasm) i. Gastrin cell tumour, functioning (gastrinoma) or nonfunctioning ii. Somatostatin cell tumour iii. EC(Enterochromafin) cell, serotonin-producing neoplasm iv. L-cell, glucagonlike peptide and PP (Pancreatic polypeptide)/PYY (Polypeptide YY)-producing tumour e. Mixed carcinoid-adenocarcinoma f. Gangliocytic paraganglioma g. Others 2. Non-epithelial tumours: a. Lipoma b. Leiomyoma c. Gastrointestinal stromal tumour d. Leiomyosarcoma e. Angiosarcoma f. Kaposi sarcoma g. Others

3. Malignant Lymphomas: a. Immunoproliferative small intestinal disease (includes alpha-heavy chain disease) b. Western type B-cell lymphoma of MALT c. Mantle cell lymphoma d. Diffuse large B-cell lymphoma e. Burkitts lymphoma f. Burkitt like or atypical Burkitts lymphoma g. T-cell lymphoma i. Enteropathy associated ii. Unspecified h. Others 4. Secondary Tumours 5. Polyps: a. Hyperplastic (metaplastic) b. Peutz-Jeghers c. Juvenile

Colon and Rectum:

1. Epithelial tumours: a. Adenoma: i. Tubular ii. Villous iii. Tubulovillous iv. Serrated b. Intraepithelial neoplasia (dysplasia) associated with chronic inflammatory diseases i. Low-grade glandular intraepithelial neoplasia

ii. High-grade glandular intraepithelial neoplasia c. Carcinoma i. Adenocarcinoma ii. Mucinous carcinoma iii. Signet-ring carcinoma iv. Small cell carcinoma v. Squamous cell carcinoma vi. Adenosquamous carcinoma vii. Medullary carcinoma viii. Undifferentiated carcinoma d. Carcinoid (Well differentiated endocrine neoplasia) i. EC cells, serotonin producing neoplasm ii. L-cell, glucagonlike peptide and PP/PYY producing tumour iii. Other e. Mixed carcinoid-adenocarcinoma f. Others 2. Non-epithelial tumours a. Lipoma b. Leiomyoma c. Gastrointestinal stromal tumour d. Leiomyosarcoma e. Angiosarcoma f. Kaposi sarcoma g. Malignanat melanoma h. Others i. Malignant Lymphomas:

i. Marginal zone B-cell lymphoma of MALT type ii. Mantle cell lymphoma iii. Diffuse large B-cell lymphoma iv. Burkitt lymphoma v. Burkitt-like/atypical Burkitt lymphoma vi. Others 3. Secondary Tumours 4. Polyps: a. Hyperplastic polyp (metaplastic) b. Peutz-Jeghers c. Juvenile