DRUG NAME Ibuprofen

DOSAGE AND ROUTE Rheumatoid arthritis, osteoarthritis, arthritis Adult: 300 to 800 mg P.O. t.i.d. or q.i.d. Maximum daily dose is 3.2 g. Mild to moderate pain, dysmenorrheal Adult: 400 mg P.O. q 4 to 6 hours, p.r.n. Fever Adults: 200 to 400 mg. P.O. q 4 to 6 hours, for no longer than 3 days. Maximum daily dose is1.2 g. Children ages 6 months to 12 years; If childs temperature is below 102.5 F (39.2 C), give 5 mg/kg P.O. q 6 to 8 hours. Treat

ACTION Unknown. May inhibit prostaglandin synthesis, to produce antiinflammatory, analgesic, and antipyretic effects.

INDICATION Ibuprofen contains the active ingredient ibuprofen, which belongs to a group of medicines called non-steroidal antiinflammatory drugs (NSAIDs). It works by blocking the action of a substance in the body called cyclooxygenase. Cyclooxygenase is involved in the production of various chemicals in the body, some of which are known as prostaglandins. Prostaglandins are produced in response to injury or certain diseases and would otherwise go on to cause pain, swelling and inflammation. Ibuprofen is therefore used to relieve pain and inflammation. All the medicines in this group (NSAIDs) reduce inflammation caused by the body's own immune system, and are effective pain killers. Ibuprofen can be used to relieve

ADVERSE EFFECTS CNS Headache, dizziness, nervousness, aseptic meningitis. CV Peripheral edema, fluid retention, edema. EENT Tinnitus GI Epigastric distress, nausea, occult blood loss, peptic ulceration, diarrhea, constipation, abdominal pain, bloating, GI fullness, dyspepsia, flatulence, heartburn, decreased appetite. GU Acute renal failure, azotemia, cystitis, hematuria. HEMATOLOGIC Plonged

CONTRAINDICATION Contraindicated in patients hypersensitive to drug and in those with angioedema, syndrome of nasal polyps, or bronchospastic reaction to aspirin or other NSAIDs. Contraindicated in pregnant women. Use cautiously in patients with GI disorders, history of peptic ulcer disease, cardiac decompensation, hypertension, asthma, or intrinsic coagulation defects.

NURSING RESPONSIBILITY Tell patient to take with meals or milk to reduce adverse GI reactions. Note: Drug is available at OTC. Instruct patient not to exceed 1.2 g daily, not to give to chidren younger than age 12, and not to take for extended periods ( longer than 3 days for fever or longer than 10 days for pain) without consulting presciber. Tell patient that full therapeutic effect for arthritis may be delayed for 2 to 4 weeks. Although pain relief occurs at low dosage levels, inflammation doesnt improve at dosages less than 400 mg q.i.d. Teach patient to watch for and report to prescriber immediately signs and symptoms of GI bleeding, including blood in vomit, urine, or stool or coffee ground vomit, and black, tarry stool. Warn patient to avoid hazardous activities that require mental

Advil, ApoIbuprofen, Motrin, Excedrin IB, Genpril, Haltran, Ibutab, Medipren, Menadol, Midol IB, Motrin, Rufen, Trendar.

higher temperatures with 10mg/kg q to 6 hours. Maximum daily dose in 40mg/kg. Juvenile arthritis Children: 30 to 40 mg/kg daily P.O. in three or four divided doses. Maximum daily dose is 50 mg/kg.

pain such as muscular aches and pains, period pains, headache, backache, rheumatic pain, dental pain and neuralgia. It can also reduce feverishness and the symptoms of colds and flu.

bleeding time, anemia, neutropenia, pancytopenia, thrombocytope nia, aplastic anemia, leucopenia, agranulocystoci s. METABOLIC Hypoglycemia, hyperkalemia. RESPIRATORY: Bronchospasm SKIN Pruritus, rash, urticaria, stevens Johnson syndrome.

alertness until effects on CNS are known. Advise patient to wear sunscreen to avoid hypersensitivity to sunlight.

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