In today's VETgirl online veterinary continuing education podcast, we review the use of intravenous lipid emulsion (ILE), otherwise known as intravenous fat emulsion (IFE), in veterinary medicine. ILE has been documented in both human and veterinary medicine as a possible antidote for fat-soluble drug toxicities such as macrocylic lactones (e.g., ivermectin, moxidectin), local anesthetics, baclofen, cholecalciferol, etc.). In this VETgirl podcast, we discuss how ILE works, what toxins it is effective for, and how to use this exciting antidote option.