In today's VETgirl online veterinary continuing education podcast, we discuss the appropriate use of antibiotics for dogs with septic peritonitis. In patients with sepsis, early antimicrobial therapy is one of the cornerstones of treatment, along with resuscitation and source control. In human medicine, a landmark study of patients with septic shock revealed that for every one hour delay in antibiotic administration for the first six hours after presentation, mortality increased by 7.6%!(1) In critically ill, septic patients, antibiotics should be started before culture and sensitivity results are generally available, right? Well, the questions remain in both human and veterinary medicine about how we should choose those antibiotics, and whether or not our choices matter.