CRISPR makes cancer cells turncoats that attack their tumor, mouse study finds
Cancer cells that have spread to distant sites have a homing instinct and migrate back to their original tumor. The experimental therapy exploits this property to attack tumors.
by Sharon Begley
Jul 11, 2018
3 minutes
As an idea for wiping out cancer, it could have been ripped from the pages of a spy thriller: Take cancer cells that have departed the original tumor and spread elsewhere in the body, genome-edit them to be stone-cold killers, then wait for the homesick cells to return and make like émigré assassins.
In a four years in the making, scientists reported on Wednesday that “rehoming” cells that had been CRISPR’d to attack cells in the original tumor improved survival in lab mice with brain
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