NPR

'Minibrains' In A Dish Shed A Little Light On Autism And Epilepsy

Experiments with small clusters of networked brain cells are helping scientists see how real brains develop normally, and what goes awry when cells have trouble making connections.
Scientists placed two clusters of cultured forebrain cells side by side (each cluster the size of a head of a pin). Within days, the "minibrains" had fused and particular neurons (in green) migrated from the left side to the right side, as subsets of cells do in a real brain.

Tiny, 3-D clusters of human brain cells grown in a petri dish are providing hints about the origins of disorders like autism and epilepsy.

An experiment using these cell clusters — which are only about the size of the head of a pin — found that a genetic mutation associated with both autism and epilepsy kept developing cells from migrating normally from one cluster of brain cells to another, researchers report in the journal Nature.

"They were sort of left behind," says , an assistant

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